Some families are more at risk of impact than others. These includes families with young children, migrant children, some of them without parents, or youth from lower income neighborhoods. The Sarphati Cohort is a study into the development and health of Amsterdam children in the city. The study aims to gain insight into what influences children’s health and to help prevent non-communicable diseases such as diabetes, obesity and cardiovascular diseases, starting from an early age. The cohort includes children receiving services from Youth Health Care (YHC) at the Public Health Service of Amsterdam (GGD Amsterdam) and the Amsterdam Health Foundation (SAG) Parent and Child Teams. The impact of COVID-19 on a selection of this cohort will be assessed through weekly telephone interviews of about 15 minutes with 20 participating parents. Telephone calls will be recorded and transcribed, stored and shared centrally (with parents’ consent). Additionally, organize online focus group meetings with parents are proposed to allow them to exchange experiences and together suggest policy-changes. Data results can be contextualized and contrasted with previously gathered data including information about nutrition, exercise, sleeping, growth, parenting and background characteristics.